The case for the link between inflammation and schizophrenia is getting stronger.
From Psychiatry Advisor
A specialized weight loss diet preferred by some bodybuilders may be effective in treating schizophrenia, according to research published in Schizophrenia Research
Although further studies using other animal models are needed to confirm these findings, the authors wrote that “as [a ketogenic diet] has been safely and effectively administered to humans in different pathological conditions, [this treatment] has the potential to be swiftly translated into a novel, safe and effective management of schizophrenia.”
Kraeuter AK, Loxton H, Lima BC, Rudd D, Sarnyai Z. Ketogenic diet reverses behavioral abnormalities in an acute NMDA receptor hypofunction model of schizophrenia. Schizophr Res. 2015; doi:10.1016/j.schres.2015.10.041.
A case report From US National Library of Medicine National Institutes of Mental Health website
Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature
We report the unexpected resolution of longstanding schizophrenic symptoms after starting a low-carbohydrate, ketogenic diet. After a review of the literature, possible reasons for this include the metabolic consequences from the elimination of gluten from the diet, and the modulation of the disease of schizophrenia at the cellular level.
C.D. is a 70 year-old Caucasian female with a diagnosis of schizophrenia since the age of seventeen. Her diagnosis was based on paranoia, disorganized speech, and hallucinations. She reported both auditory and visual hallucinations, including seeing skeletons and hearing voices that told her to hurt herself. According to her history, she has had these hallucinations on almost a daily basis since the age of seven. C.D. has also been hospitalized at least five times over the last six years for suicide attempts and increased psychotic symptoms. She has attempted to overdose on medications, cut herself, and ingest cleaning agents. Her most recenthospitalization was five months prior to initiating the low-carbohydrate diet. She has discussed both her suicidal ideations and her hallucinations with her psychiatrist who has tried to optimize her medication regimen in an effort to improve her symptoms, but this has been largely unsuccessful. Her prior anti-psychotic and mood-stabilizing medication regimen has included lithium 900 mg qhs, olanzapine (dose unknown), ziprasidone 40 mg bid, aripiprazole 30 mg qhs, lamotrigine 100 mg bid, and quetiapine 900 mg qhs. She is currently managed on risperidone 4 mg qhs.